Temporary trend of breast cancer mortality in the state of Santa Catarina in the period from 1996 to 2019

Introduction: Breast cancer is the most common female cancer and the leading cause of cancer death in women around the world. It has repercussions not only on human health, but also on health services due to the high incidence resulting in a large number of consultations and treatments. The disease is responsible for a large demand for hospitalizations throughout Brazil, where an increase in mortality rates is observed and Santa Catarina does not differ from the national scenario. The study aimed to analyze the temporal trend of the breast cancer mortality rate in the state of Santa Catarina from 1996 to 2019 Methods: This is an ecological epidemiological study of time series of breast cancer mortality in the population residing in the state according to age groups and health macro-regions. Data were obtained from the Mortality Information System and the Brazilian Institute of Geography and Statistics. Simple linear regression of standardized mortality rates according to the world standard population was performed. p<0.05 was considered significant. Results: Data showed 9,637 deaths in the period. There was a significant upward trend in mortality in the state (from 6.50 to 7.92/100,000 women). An upward trend was observed in the age groups of 30­39 years, 60­69 years, and over 80 years. All seven health macro-regions showed an upward trend in mortality. Conclusion:The overall mortality rate from breast cancer in Santa Catarina showed a significant upward trend. A significant increase was also observed in the age groups of 30­39 years, 60­69 years, and 80 years old or older and in all health macro-regions. Problems in public health infrastructure, lack of control of risk factors and deficiency in mammographic screening are revealed. The elaboration and strengthening of public policies to control the disease are fundamental.

Germline genetic mutations in high-risk patients for breast cancer: profile of a group in the city of Florianopolis, Santa Catarina

To analyze the occurrence of genetic mutations in a sample of patients with high risk of breast cancer in Florianopolis/ SC from December 1st, 2021, to January 31, 2022. Methods: An observational, descriptive and retrospective study carried out through data collection of a preexisting database. A total of 194 tests were analyzed. Of these, 192 met the inclusion criteria and composed the final sample of 205 genes. Data were classified and reported the frequency and percentage of the variables: gene and presence or absence of mutation. Results: Mean age of the analyzed patients was 52.3 years, and most underwent the test due to personal history of breast cancer (80%). Clinical significance classification showed that, of the 192 gene panels, 62% were variants of uncertain significance; 14% were pathogenic; and 24%, negative. Of the 205 mutations, the most prevalent genes were: ATM 8.7%, MUTYH 5.8%, POLE 5.8%, BRCA2 4.8%, MSH6 4.8% and RECQL4 4.8%. Of the pathogenic tests regarding genetic predisposition to cancer (n=38/14.1%), the most common mutations were MUTYH (23%) and BRCA1 (15%), with mean age of 52 years (±14.3). In variants of uncertain significance panels (n=168/62%) the frequency rates were ATM (7.7%), POLE (7.1%) and MSH6 (5.9%) genes. The high penetrance genes were present in 18% of the genetic predisposition to cancer panels. Of those with positive family history (n=40), 19% of the genes were pathogenic, 53% were variants of uncertain significance; and 26% were negative. Furthermore, in patients with pathogenic mutations and positive family history (n=11), the most common mutations were in BRCA1 (27%) and BRCA2 (27%). Of the patients who tested due to personal history (n=152), 64% of the genes presented variants of uncertain significance, 13% were pathogenic and 22% were negative.

Avaliação da resistência ao cisalhamento e miniflexão de resinas ortodônticas associadas ao primer / Evaluation of the shear bond and mini flexural strength of the orthodontics resins associated with primer

O objetivo desse estudo foi avaliar o efeito da aplicação do primer na resina na resistência ao cisalhamento e flexão em compósitos para colagem ortodôntica. Foram colados braquetes em 60 pré-molares humanos com as resinas Orthobond (G1), Z100 (G2) e Transbond XT (G3). Nos grupos 1, 2 e 3 a colagem foi feita de modo convencional, com a aplicação do primer na superfície condicionada. Nos grupos 4, 5 e 6 o primer foi aplicado na resina presente no braquete. Para o teste de flexão, nos grupos 1, 2 e 3 foram confeccionadas barras com as resinas Orthobond, Z100 e Transbond XT sem misturar com o primer. Nos grupos 4, 5 e 6 o primer foi aplicado nas resinas durante a confecção das barras. Os ensaios de resistência ao cisalhamento e flexão de três pontos foram realizados em máquina Instron com velocidade de 1,0 mm/minuto. Os resultados foram submetidos à Anova dois fatores e ao teste de Tukey (α=0,05). Os resultados mostraram que o Transbond XT apresentou resistência ao cisalhamento significativamente maior do que os outros materiais, e que não houve diferença significante quanto ao método de aplicação do primer. No teste de flexão, a resina Orthobond apresentou resistência significativamente menor do que os outros materiais, e a adição do primer reduziu significativamente a resistência à flexão dos materiais. Concluiu-se que a adição do primer na resina reduziu a resistência à flexão dos materiais e não alterou a resistência de união de braquetes ao esmalte. Dentre as resinas, o melhor desempenho foi apresentado pela Transbond XT...

The aim of this study was to evaluate the effect of primer application in shear bond and flexural strength of composite for orthodontic bonding. Brackets were bonded in 60 human premolars with Orthobond (G1), Z100 (G2) and Transbond XT (G3). In groups 1 to 3 the bond was done in a conventional manner with the application of the primer in the etched surface. In groups 4 to 6 the primer was applied on the primer resin in this bracket. For the flexural test, in groups 1-3 bars were made with the Orthobond, Z100 and Transbond XT without mixing with the primer. In groups 4 to 6 primer was applied to the resin during the manufacture of the bars. Shear bond test and flexural three points test were performed in Instron machine with a speed of 1.0 mm/minute. The results were submitted to Anova two factors and Tukey's test (α=0.05). The results showed that Transbond XT showed significantly higher shear bond resistance than the other materials; there was no significant difference in the primer application method. In the flexural test, the resin Orthobond showed significantly lower resistance than the other materials; adding the primer significantly reduced the flexural strength of the materials. It is concluded that the addition of the primer resin reduced the flexural strength of the material and did not alter the bond strength of brackets to enamel. Among the resins, the best performance was presented by Transbond XT...

Fraturas da face / Facial bone fractures

A violência e o trânsito nas grandes cidades, juntamente com a mecanização do trabalho agrícola, tem contribuído para aumentar a incidência de traumas e fraturas dos ossos da face. Estes casos devem ser tratados adequadamente para minimizar sequelas estéticas e funcionais e reintegrar o mais rápido possível o indivíduo ao seu meio. Foi realizado levantamento de 159 casos de trauma da face atendidos nos ultimos 24 meses no SETPF do HMSVP e analisada a correlação entre o agente etiológico e a frequência dos diversos tipos de trauma, sendo constatado que o principal causador foi o acidente de trânsito (32 por cento) e a fratura mais encontrada, a de mandíbula (33 por cento)

Un caso de adenocarcinoma bronquial que se manifestó por disfagia / A case of bronchial adenocarcinoma manifested by dysphagia

Se presenta el caso de un paciente de 66 años de edad con antecedente de tabaquismo moderado en su juventud y padecimiento de un mes de evolución, caracterizado por disfagia al inicio a sólidos y después de 20 días a líquidos. Tenía síndrome de derrame pleural izquierdo de 100 por ciento. Se manejo mediante toracocentesis y pleurodesis química por recidiva del derrame, el cual persistió en 30 por ciento. El reporte histopatológico fue de adenocarcinoma bronquial primario